Effie C. Tsilibary, MD PhD
Adjunct Associate Professor, Neuroscience, University of Minnesota
tsili001@umn.edu
Education
PhD, Cell Biology & Anatomy, University of California, San Francisco
MD, Medical School, National University of Athens
Specialty/Focus
Molecular mechanisms of cell-matrix interactions
Cell signaling and survival in pathological conditions and neurodegenrative diseases
Cell biology and biochemistry
Vaccines
Gulf War IllnessGulf War Illness (GWI)Shortly after the Gulf War (1990-91), veterans started to report a variety of health problems that began during, or soon after returning from, deployment, prompting investigation into the epidemiology and etiology of the complaints. Those investigations revealed that diffuse symptoms such as fatigue, musculoskeletal pain, mood and neurocognitive complaints, gastrointestinal problems, and rashes were most commonly reported. The constellation of symptoms, now commonly referred to as Gulf War Illness (GWI), has affected a substantial number of Gulf War veterans. Several population-based studies have demonstrated that these symptoms occur at significantly higher rates in deployed Gulf War veterans relative to their nondeployed peers and other veterans, raising the issue about possible in-theater exposures and stress as contributing factors. However, these symptoms are also present in non-deployed military personnel, leading some to suspect other causes, including reactions to vaccine adjuvants. In summary, GWI is now a recognized constellation of symptoms of unclear etiology, also co-occurring with psychiatric disorders.
Dementia
Neurodegenerative diseases
Publications
Pages:
1August 2021 through August 2016 •
2July 2016 through December 2007 •
3November 2007 through December 1993 •
4May 1993 through June 1985 •
5November 1983 through May 1977An Apolipoprotein EApolipoprotein E (ApoE)a plasma lipoprotein discovered in 1973 (Shore and Shore 1973). It binds low-density lipoprotein receptors, thereby facilitating cellular lipoprotein exchange and metabolism. The human apoE polypeptide consists of 299 amino acids and comprises three polymorphisms resulting from single amino acid substitutions. Three isoforms (E4, E3, and E2) are the result of cysteine^aEUR"arginine interchanges at two sites, namely residues 112 and 158; however, other genetic variants have been described. These three isoforms, each differentially affecting protein function, result in six phenotypes: three homozygotes (E4/4, E3/3, E2/2) and three heterozygotes (E4/3, E4/2, E3/2). With respect to the number of cysteine residues per mole, E2/2 contains 4, E3/2 contains 3, E4/2 and E3/3 each contain 2, E4/3 contains 1, and E4/4 contains 0. The number of cysteine residues per mole (CysR/mole) provides a numerical, biochemical scale in lieu of the genotype-based categories.4 fragment affects matrix metalloproteinase 9, tissue inhibitor of metalloproteinase 1 and cytokine levels in brain cell lines Neuroscience (2012, May) Dafnis I, Tzinia AK, Tsilibary EC, Zannis VI, & Chroni A Rapid magnetic heating treatment by highly charged maghemite nanoparticles on Wistar rats exocranial glioma tumors at microliter volume Biomicrofuidics (2010, June) Rabias I, Tsitrouli D, Karakosta E, Kehagias T, Diamantopoulos G, Fardis M, Stamopoulos D, Maris TG, Falaras P, Zouridakis N, Diamantis N, Panayotou G, Verganelakis DA, Drossopoulou GI, Tsilibary EC, & Papavassiliou G An ApoEApolipoprotein E (ApoE)a plasma lipoprotein discovered in 1973 (Shore and Shore 1973). It binds low-density lipoprotein receptors, thereby facilitating cellular lipoprotein exchange and metabolism. The human apoE polypeptide consists of 299 amino acids and comprises three polymorphisms resulting from single amino acid substitutions. Three isoforms (E4, E3, and E2) are the result of cysteine^aEUR"arginine interchanges at two sites, namely residues 112 and 158; however, other genetic variants have been described. These three isoforms, each differentially affecting protein function, result in six phenotypes: three homozygotes (E4/4, E3/3, E2/2) and three heterozygotes (E4/3, E4/2, E3/2). With respect to the number of cysteine residues per mole, E2/2 contains 4, E3/2 contains 3, E4/2 and E3/3 each contain 2, E4/3 contains 1, and E4/4 contains 0. The number of cysteine residues per mole (CysR/mole) provides a numerical, biochemical scale in lieu of the genotype-based categories.4 fragment can promote intracellular accumulation of amyloid peptide beta 42 Journal of Neurochemistry (2010, April) Dafnis I, Stratikos E, Tzinia AK, Tsilibary EC, Zannis VI, & Chroni A