James Ashe, M.D.
Principal Investigator, Brain Sciences Center
Professor, Neuroscience and Neurology, University of Minnesota
Director, Movement Disorder Clinic, VA Medical Center Minneapolis  

Specialties
Motor Control, Motor Learning and Adaptation,
Neural Basis of Decision Making, Disorder of Human Movement  

Education
M.D. Residency, Neurology, Johns Hopkins Univ., Baltimore, MD.
M.D, Neurology, Johns Hopkins Univ., Baltimore,
MD. University College, Dublin, Ireland  

Selected Publications

• Lungu OV,Wächter T, Liu T, Willingham DB, Ashe J (2004) Probability detection mechanisms and motor learning. Experimental Brain Research 159:135-50
• Ashe J (2004) What is coded in the primary motor cortex. In: Motor Cortex in Voluntary Movements (Riehle A, Vaadia E, eds.), Baton Rouge, CRC Press, pp 141-156
• Lu X, Ashe J (2005) Anticipatory activity in primary motor cortex codes for upcoming movement sequences. Neuron 24:967-73
• Seidler RD, Purushotham A, Kim S-G, Ugurbil K, Willingham D, Ashe J (2005). Neural substrates for encoding and expression of implicit learning. Experimental Brain Research. 165: 114-124
• Boline J, Ashe J (2005) On the relations between single cell activity in the motor cortex and the direction and magnitude of three-dimensional dynamic isometric force. Experimental Brain Research 167: 148-59
• Ashe J, Lungu OV, Basford AT, Lu X (2006). Cortical control of motor sequences. Current Opinion in Neurobiology 16:213-21 Xu D, Liu T, Ashe J, Bushara K (2006) Role of the olivo-cerebellar system in timing. Journal of Neuroscience 26: 5990-95
• Gupta R, Ashe J (2007) Lack of adaptation to random conflicting force fields of variable magnitude. Journal of Neurophysiology 97: 738-45 Chafee MV, Ashe J (2007) Intelligence in Action. Nature Neuroscience 10: 142-143
• Seidler R, Tuite P, Ashe J (2007) Selective impairments in implicit learning in Parkinson’s disease. Brain Research 1137:104-10
• Bares M, Lungu O, Liu T, Wachter T, Gomez C, Ashe J (2007) Impaired predictive motor timing in patients with cerebellar disease. Experimental Brain Research 180: 355-365
• Lungu OV, Liu T, Waechter T, Willingham DT, Ashe J (2007) Strategic modulation of cognitive control. Journal of Cognitive Neuroscience 19:1302-15
• Liu T, Lungu OV, Wachter T, Willingham DT, Ashe J (2007) Frames of reference during implicit and explicit learning. Experimental Brain Research 180: 273-280
• Knee R, Thomason S, Ashe J, Willingham DT (2007). The representation of explicit motor sequence knowledge. Memory and Cognition 35:326-33
• Keisler A, Ashe J, Willingham DT (2007) Time of day accounts for overnight improvement in sequence learning. Learning and Memory 14:669-72
• Seidler RD, Ashe J (2007) Procedural Learning: Cerebellum Models in The New Encyclopedia of Neuroscience (Ed. L Squire). Elsevier
• Liu T, Xu J, Ashe J, Bushara K (2008) The Specificity of Inferior Olive Response to Stimulus Timing. Journal of Neurophysiology 100:1557-61
• Witt JK, Ashe J, Willingham DT (2008). An egocentric frame of reference in implicit motor sequence learning. Psychology Research 72:542-52. Wachter T, Lungu OV, Liu T, Willingham DT, Ashe J (2009) Differential effect of reward and punishment on procedural learning. Journal of Neuroscience 29: 436-443
• Gupta R, Ashe J (2009) Off-line decoding of End-Point forces using neural ensembles: Application to a Brain-Machine Interface. IEEE Transactions on Neural Systems and Rehabilitation Engineering (in the press)